Oral peptide delivery is especially challenging for insulin tablets due to enzymatic degradation and low permeability in the gastrointestinal tract. This brief video presentation highlights the key barriers and emerging strategies that aim to make oral insulin a practical therapeutic…
This article is part of the series “Delivery Systems in Simple Terms.” 1. Nanoemulsions — simple delivery system What they are How they work Key mechanisms Advantages Limitations 2. Liposomes — a membrane‑based delivery system What they are How they…
Bioavailability is a class-dependent property, governed by distinct limiting mechanisms for small molecules versus biologics. While the formal definition of bioavailability remains unchanged, the dominant barriers, failure modes, and formulation levers differ substantially depending on molecular size, polarity, and susceptibility…
Bioavailability (F) is formally defined as the fraction of an administered dose of an active pharmaceutical ingredient (API) that reaches the systemic circulation in an unchanged form, integrating both absorption efficiency and the impact of first-pass metabolism. For orally administered…
PHARCON Inc. develops self‑nanoemulsifying drug delivery systems (SNEDDS) to enhance the delivery of poorly water‑soluble biologically active compounds. SNEDDS significantly improve solubility, absorption, bioavailability, and overall therapeutic performance. COMPARATIVE DISSOLUTION OF SNEDDS AND OIL-FILLED CAPSULES Copyright © 2026 PHARCON Inc.…
This is where formulation science and bioavailability come together. Instead of changing the drug itself, scientists change how it’s delivered. 1. Improving solubility in formulation science Formulation techniques can: This helps the compound stay dissolved long enough to be absorbed.…
Bioavailability, in simple terms Bioavailability describes how much of a drug or active compound actually reaches your bloodstream and can start working. You may swallow a full dose, but your body often absorbs only a part of it. In many…
Research & Development Advancing the Science of Delivery Pharcon’s R&D programs focused on solving the challenges associated with poorly absorbable compounds. Our work spans pharmaceutical, nutraceutical, cosmeceutical and hybrid formulations, with an emphasis on improving solubility, permeability, bioavailability of biologically…
